Deep Eutectic Mixture Catalyzed One-Pot Three-Component Synthesis of 1H-Pyrazolo and 2H-Indazolo [1,2-b] Phthalazines
Sandip K. Lanke, Santosh B. Chemate, Atul Chaskar and N. SekarAffiliation:
Department of Dyestuff Technology Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai - 400 019, India.
AbstractA direct, simple and green protocol describes synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-diones and 2H-indazolo[2,1-b] phthalazine-triones derivatives using deep eutectic mixture(choline chloride: malonic acid) as a homogeneous catalyst as well as solvent at reflux temperature. A method provides significant advantages such as short reaction times, easy workup procedure, high yields, atom economy and recyclability of catalyst.
Aldehydes, aqueous medium, deep eutectic mixture, 2, 3-dihydrophthalazine-1, 4-dione, 5, 5-dimethylcyclohexane- 1, 3-dione, ethylcyanoacetate, malononitrile
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