Evaluation of Role of Oxidative Stress on Aging in Caenorhabditis elegans: A Brief Review

ISSN: 1874-6128 (Online)
ISSN: 1874-6098 (Print)

Volume 10, 4 Issues, 2017

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Current Aging Science

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Prof. Debomoy K. Lahiri
Department of Psychiatry Indiana University School of Medicine
Indianapolis, IN

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Evaluation of Role of Oxidative Stress on Aging in Caenorhabditis elegans: A Brief Review

Current Aging Science, 6(3): 215-219.

Author(s): Kedar N. Prasad and Stephen C Bondy.

Affiliation: Antioxidant Research Institute, Premier Micronutrient Corporation, 14 Galli Drive, Suite 200, Novato CA 94949, USA.


Recently the relationship between oxidative stress and aging has been brought into question. It has been suggested that while oxidative events may play a role in the progression of age-related pathologies, it is not relevant to aging processes not involving specific diseases associated with senescence. The evidence in support of this concept is largely based on studies with the roundworm, Caenorhabditis elegans (C. elegans) that has been extensively used as a model system to study aging. This commentary evaluates data derived from C. elegans and documents that the preponderance of evidence from this species supports the role of pro-oxidant events as being a significant contributor to normal aging. Possible reasons for some anomalous findings conflicting with this concept, are discussed.


Antioxidants, aging, Caenorhabditis elegans, lifespan, oxidative stress, superoxide.

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Article Details

Volume: 6
Issue Number: 3
First Page: 215
Last Page: 219
Page Count: 5
DOI: 10.2174/18746098112059990031
Price: $58

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