The Normal and Pathologic Roles of the Alzheimer's β -secretase, BACE1

ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)


Volume 11, 10 Issues, 2014


Download PDF Flyer




Current Alzheimer Research

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 38th of 194 in Clinical Neurology
  • 80th of 251 in Neurosciences

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Prof. Debomoy K. Lahiri
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Cente
Indianapolis, IN 46202
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.796
5 - Year: 3.998

The Normal and Pathologic Roles of the Alzheimer's β -secretase, BACE1

Author(s): Patty C. Kandalepas and Robert Vassar

Affiliation: Northwestern University, Feinberg School of Medicine, Department of Cell & Molecular Biology, 300 E. Superior, Tarry 8-713, IL 60611, Chicago.

Abstract

As the most common neurodegenerative disease, therapeutic avenues for the treatment and prevention of Alzheimer’s Disease are highly sought after. The aspartic protease BACE1 is the initiator enzyme for the formation of Aβ , a major constituent of amyloid plaques that represent one of the hallmark pathological features of this disorder. Thus, targeting BACE1 for disease-modifying AD therapies represents a rationale approach. The collective knowledge acquired from investigations of BACE1 deletion mutants and characterization of BACE1 substrates has downstream significance not only for the discovery of AD drug therapies but also for predicting side effects of BACE1 inhibition. Here we discuss the identification and validation of BACE1 as the β -secretase implicated in AD, in addition to information regarding BACE1 cell biology, localization, substrates and potential physiological functions derived from BACE1 knockout models.

Keywords: Alzheimer’s disease, BACE1, beta-secretase.

Purchase Online Rights and Permissions

  
  



Article Details

Volume: 11
Issue Number: 5
First Page: 441
Last Page: 449
Page Count: 9
DOI: 10.2174/1567205011666140604122059
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science