Altered Amplitude of Low-Frequency Fluctuations in Early and Late Mild Cognitive Impairment and Alzheimer's Disease

ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)


Volume 11, 10 Issues, 2014


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Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202
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Altered Amplitude of Low-Frequency Fluctuations in Early and Late Mild Cognitive Impairment and Alzheimer's Disease

Author(s): P Liang, J Xiang, H Liang, Z Qi, N Zhong, K Li and Alzheimer’s Disease NeuroImaging Initiative

Affiliation: Capital Medical University, 45 Chang Chun Street, Xuan Wu District, Beijing 100053, China

Abstract

Purpose: Previous studies have shown that the strength of the low frequency fluctuation in the medial-line brain areas are abnormally reduced in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients. The purpose of this study was to explore the functional brain changes in early MCI (EMCI) and late MCI (LMCI) patients by measuring the amplitude of the blood oxygenation level dependent (BOLD) functional MRI (fMRI) signals at rest. Materials and methods: 35 elderly normal controls (NC), 24 EMCI, 29 LMCI, and 14 AD patients from the Alzheimer’s Disease Neuroimaging Initiative (ADNI2) were included in this study. Resting state fMRI and 3D structural MRI data were acquired. The spatial patterns of spontaneous brain activity were measured by examining the amplitude of low-frequency fluctuations (ALFF) of BOLD signal during rest. A one-way analysis of variance (ANOVA) was then performed on ALFF maps, with age, sex and regional atrophy as covariates. Results: There were widespread ALFF differences among the four groups. As compared with controls, AD, LMCI and EMCI patients showed decreased ALFF mainly in the posterior cingulate cortex, precuneus, right lingual gyrus and thalamus (with a linear trend: NC>EMCI>LMCI>AD), while there was increased activity in the right parahippocampal gyrus (with a linear trend: NC

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Article Details

Volume: 11
First Page: 1
Page Count: 1
DOI: 10.2174/1567205011666140425113143
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