Current advancements in Ab luminescent probes and inhibitors of Ab aggregation

ISSN: 1875-5828 (Online)
ISSN: 1567-2050 (Print)


Volume 11, 10 Issues, 2014


Download PDF Flyer




Current Alzheimer Research

Aims & ScopeAbstracted/Indexed in

Ranking and Category:
  • 35th of 193 in Clinical Neurology
  • 80th of 252 in Neurosciences

Submit Abstracts Online Submit Manuscripts Online

Editor-in-Chief:
Prof. Debomoy K. Lahiri
Department of Psychiatry Indiana University School of Medicine
Indianapolis, IN
USA


View Full Editorial Board

Subscribe Purchase Articles Order Reprints

Current: 3.676
5 - Year: 4.203

Current advancements in Ab luminescent probes and inhibitors of Ab aggregation

Author(s): C-H Leung, DS-H Chan, VP-Y Ma, K-H Leung and H-J Zhong


Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder that severely jeopardizes the health of aging populations all over the world. According to the amyloid cascade hypothesis, the pathological progression of AD is associated with the formation of amyloid plaques in the brain, resulting from the aggregation of amyloid-b (Ab) peptides. Over the past few years, vast efforts have been dedicated to the development of amyloid probes and inhibitors for the diagnosis and effective treatment of AD. We review here recent advancements in luminescent probes for the detection of Ab peptide and fibrils, and the current development of small molecules inhibitors of Ab aggregation. We also highlight the key features in each specific example, as well as review new ideas and strategies that are crucial for researchers in this field.


Purchase Online Rights and Permissions

Article Details

Volume: 10
First Page: 1
Last Page: 1
Page Count: 1
DOI: 10.2174/15672050113109990010
Advertisement

Related Journals




Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science