Synthesis and Pharmacological Studies of Novel 3-Substituted Indole Derivatives as Potential Anti-Inflammatory and Analgesic Agents

ISSN: 2212-7046 (Online)
ISSN: 2212-7038 (Print)


Volume 1, 2 Issues, 2014






Clinical Anti-Inflammatory & Anti-Allergy Drugs

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Editor-in-Chief:
Giovanni Passalacqua
Allergy & Respiratory Diseases
Department of Internal Medicine
University of Genova
Genova
Italy


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Synthesis and Pharmacological Studies of Novel 3-Substituted Indole Derivatives as Potential Anti-Inflammatory and Analgesic Agents

Author(s): Mayura A. Kale, Ashok S. Narute and Tukaram M. Kalyankar

Affiliation: Government College of Pharmacy, opposite Government Polytechnic, Railway station road, Osmanpura, Aurangabad (M.S), India - 431 005.

Abstract

Facile synthesis of some novel anti-inflammatory and analgesic agents was established by initially treating 3- acetyl indole (1) with the various aromatic aldehydes (2) which afforded the corresponding 3-chalconylindoles 3a-e. These products 3a-e upon treatment with hydrazine hydrate gave the resultant pyrazoline derivatives 4a-e. Also, the diazotized salt of aniline, when reacted with these pyrazoline indoles 4a-e yielded azo derivatives of pyrazoline indoles 5a-e. These newly synthesized compounds were screened for the mentioned activities and were found to possess good potential to act against inflammation and pain.

Keywords: Analgesic & indomethacin, anti-inflammatory, azo derivatives, indole, pyrazoline.

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Article Details

Volume: 1
Issue Number: 1
First Page: 39
Last Page: 44
Page Count: 6
DOI: 10.2174/2212703801666131209232632
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