Quantization of Angiogenesis and Image Analysis

ISSN: 2211-5536 (Online)
ISSN: 2211-5528 (Print)

Volume 4, 2 Issues, 2015

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Current Angiogenesis

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Guo-Chang Fan, PHD
Dept. of Pharmacology and Cell Biophysics
University of Cincinnati College of Medicine

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Quantization of Angiogenesis and Image Analysis

Current Angiogenesis, 3(4): 245-249.

Author(s): Nikolaos Kavantzas, Vasileios Salpeas, Eleftheria Lakiotaki and Petros M Pavlopoulos.

Affiliation: First Department of Pathology, School of Medicine, University of Athens, 75 Mikras Asias str. GR-11527, Athens Greece


Quantitative Pathology is engaged with the determination of morphological characteristics of tissues. One important field of measurement is the estimation of angiogenesis in malignant neoplasms. The parameters of angiogenesis that are determined include: microvascular density (MVD), total vascular area (TVA) and vessel’s major axis length, minor axis length, area, perimeter, compactness, shape factor and Feret diameter [1-3]. The statistical correlations of the above mentioned parameters with prognosis or clinicopathological characteristics result in conclusions about the malignant potential and aggressiveness of different malignant tumors. In the present review article, we identify basic morphometric parameters used to characterize angiogenesis and describe the method of quantization by the appropriate image analysis software.


Angiogenesis, image analysis.

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Article Details

Volume: 3
Issue Number: 4
First Page: 245
Last Page: 249
Page Count: 5
DOI: 10.2174/2211552802666140104000902

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