Derivatization Coupled to Chemiluminescence Detection

ISSN: 1875-6727 (Online)
ISSN: 1573-4110 (Print)

Volume 11, 4 Issues, 2015

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Current Analytical Chemistry

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Samuel Achilefu
Washington University
St. Louis, MO

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Derivatization Coupled to Chemiluminescence Detection

Current Analytical Chemistry, 10(3): 305-319.

Author(s): George Z. Tsogas, Dimosthenis L. Giokas and Athanasios G Vlessidis.

Affiliation: Laboratory of Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece.


In this work, an overview of analytical methods employing derivatization reactions in chemiluminescence detection is presented. Method development, instrumental configurations and hyphenated manifolds, specifically designed or implemented to accommodate CL detection, along with their analytical applications for the determination of a wide variety of organic compounds such as biochemically active substances, pharmaceutical active compounds, environmental pollutants and food constituents, are summarized. The analytical merits of derivatization reactions in chemiluminescence analysis and their potential for the development of sensitive and selective methods are elucidated.


Chemiluminescence, derivatization, liquid chromatography, capillary electrophoresis.

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Article Details

Volume: 10
Issue Number: 3
First Page: 305
Last Page: 319
Page Count: 15
DOI: 10.2174/1573411010999131219101823

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