In nature lies the solution to restore teeth with minimal damage. In this groundbreaking book, the management of dental challenges is presented from a new perspective. Natural Conservative Dentistry: An Alternative Approach to Solve Restorative Problems provides evidence-based solutions to dental challenges to researchers, practitioners and dental service providers. The main attribute of all these solutions is that they are all derived from natural ingredients. Natural ingredients are an effective alternative for dental care and management in contrast to synthetic products that have multiple side effects. This book fills a knowledge gap on alternative and sustainable solutions derived from nature to respond effectively to dental challenges encountered in dental treatment for the conservation of the tooth. It is a compilation of the work of expert dentists that has been carried out in clinics for the management of dental problems. Key Features - Provides an insightful look at the prevention of dental diseases through evidence-based interventions using natural products in 8 referenced chapters - Contains valuable contributions in restorative dentistry, such as caries prevention, enamel and dentin remineralization, dentin biomodification, dentin desensitization, vital pulp therapy, antioxidants, and tooth bleaching - Provides an update on the current status of different ingredients used in oral health care products developed for commercial markets - Includes notes on pathophysiology and diagnosis on specific conditions and sources of natural ingredients The book is a valuable reference for trainees and professionals who want to enhance their restorative dentistry practice in the clinic.

Geriatric Anesthesia: A Practical Guide is a comprehensive reference on geriatric anesthesia. The book is divided into three sections. The first section covers the basics of both anatomical and physiological changes in senescence, and important polypharmacy considerations common in elderly patients. The next section covers anesthesia for cardiac and non-surgical patients. Various controversies and legal ethical issues that are particularly significant in the elderly such as advance directives, code status discussions, specific patient groups and shared decision-making prior to surgical interventions, are covered in the final section. Key features - 20 referenced chapters covering basic geriatric anesthesia considerations, cardiac and non-surgical patients and special topics, respectively - Contributions and references from experienced anesthesiologists - Emphasis on tailoring perioperative management depending on specific circumstances of patients - Addresses novel and commonly overlooked topics related to the geriatric population This book is a guide for both anesthesia providers and non-anesthesia medical providers, trainees and students. It equips them with necessary information to understand and devise anesthetic plans while being aware of postoperative complications and the respective treatment and management options.

Textbook of Advanced Dermatology: Pearls for Academia and Skin Clinics is an essential reference for practicing dermatologists in hospitals and clinics. The book aims to provide interesting tips that cannot be found in traditional dermatology handbooks. The contributors include top minds in dermatology and related fields such as Joe Niamtu, Samuel Lam, and Steven Feldman. Topics in the book include novel, original formulations for topical compounds, ways to improve patient adherence to prescriptions, business tips, novelties in skin surgery, and solutions for preventing patient complaints and legal suits. The book also highlights the author's personal experiences gained over many years in improving everyday clinical dermatology practice. The book is divided into 5 sections each representing 'pearls' of advice: Teaching Pearls, Medical Pearls, Publication Pearls, Procedural Pearls, and Business Pearls, encompassing all of the broad realm of dermatology.

Inflammation triggers specific metabolic pathways and if not resolved, translates into several painful diseases such as rheumatoid arthritis, lupus, Alzheimer's disease, cardiovascular disorders and psoriasis. Various processes have been explored to understand the factors behind inflammation and consequently, many mechanisms have been examined to suppress it. The nucleotide-binding domain like receptor 3 (NLRP3) inflammasome is an example of such factors which is responsible for triggering sterile and microbe induced inflammation. Studies of genetic variants of the related gene have revealed insights into the mRNA expression pathways that may help researchers to identify crucial disease mechanisms. This book is a review of the scientific findings of distinguished scholars who have studied NLRP3 inflammasome activation and its contribution in worsening the outcomes of inflammatory disorders. This collection of chapters covers many aspects of the multifaceted role of NLRP3 inflammasome. Beginning with airway inflammation and fibrosis, it progresses to explore its involvement in pulmonary hypertension, heart diseases, tuberculosis, cardiovascular complications, and childhood asthma. Additionally, it examines the inflammasome's impact on protozoan parasitic infections and neuropathic pain. The chapters not only elucidate the intricate mechanisms of NLRP3 activation but also discuss potential inhibitors and therapeutic targets. Readers will gain a comprehensive understanding of the NLRP3 inflammasome's diverse implications across different physiological contexts. The book includes references making this book a valuable treatise of insights for researchers, clinicians, and healthcare professionals.

Morphea and Related Disorders is a comprehensive reference on morphea. The book covers the subject in 20 chapters. The book starts with a detailed introduction and history of the morphea and its various classifications systems. Next, the book progresses into epidemiology, predisposing factors and pathogenic mechanisms, followed by histopathology for morphea diagnosis and a detailed review of clinical presentations. Subsequent chapters cover associated diseases and extracutaneous manifestations, medical investigations, treatment guidelines and special topics (Idiopathic atrophoderma of Pasini and Pierini, Linear atrophoderma of Moulin, Parry-Romberg syndrome, Lichen sclerosus, pediatric morphea and eosinophilic fasciitis). Key features: -he most detailed reference book on morphea -Easy and simple language for readers -Chapter synopsis at the beginning of each chapter -Learning points at the end of the chapter -More than 100 high resolution colored photographs -Information boxes and tables to enhance readability. -Covers basic knowledge on morphea, including pathogenesis, clinical presentations, and classification -Includes guidelines for professionals -Includes chapters on special topics for advanced readers Morphea and Related Disorders is the definitive reference book for medical students, residents, instructors, and physicians.

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in neurology and allied disciplines. The twelfth volume of this series features these reviews: Chapter 1: Recent Drugs Tested in Clinical Trials for Alzheimer's and Parkinson's Diseases Treatment: Current Approaches in Tracking New Drugs Chapter 2: Neurobiology of Placebo: Interpreting Its Evolutionary Origin, Meaning, Mechanisms, Monitoring, and Implications in Therapeutics Chapter 3: Role of Gut Microbiota in Neuroinflammation and Neurological Disorders Chapter 4: The Role of Age in Pediatric Tumors of the Central Nervous System Chapter 5: Drug Repurposing in CNS and Clinical Trials: Recent Achievements and Perspectives Focusing on Epilepsy and Related Comorbidities Chapter 6: Progress on the Development of Oxime Derivatives as a Potential Antidote for Organophosphorus Poisoning .

Stem cells with self-renewal and multi-lineage differentiation potential have potential for developing medicines for a range of refractory and recurrent disease. This book mainly focuses on the landscape of the biological properties and translational research of stem cells types, including hematopoietic stem cells (HSCs), neural stem cells (NSCs) and mesenchymal stem/stromal cells (MSCs). The book also introduces readers to the current updates and development prospects of stem cells in singular or combination therapies with advanced biomaterials and technological innovations towards large-scale standardization and productization. Key Features: - Introduces readers to stem cell biology and tissue engineering - Covers innovations in stem cell therapy and biomaterials - Includes a brief guide to commercialization of stem cell technology - Includes references for advanced readers The contents will strengthen the reader’s understanding of stem cell-based therapies. This book is a primer on stem cell and regenerative medicine for a wide readership including students, healthcare professionals, researchers and general readers.

Marine Biopharmaceuticals: Scope and Prospects is a collaboration of experts in pharmacology, biology and biochemistry with a focus on Marine Bioprospecting. The book provides an in-depth exploration of promising pharmaceutical compounds found in various marine biota and their therapeutic applications. The comprehensive contents cover marine ecosystems, marine biopharmaceutical, and delve into the chemistry and therapeutic applications of compounds from diverse marine organisms such as seaweeds, sponges, cnidarians, bryozoans, worms, shellfish, tunicates, and fishes. The chapters also highlight approved and marketed marine biota-derived drugs and marine biota-derived drug candidates currently under clinical trials. Marine biopharmaceutical compounds targeting SARS-CoV-2 are also covered, reflecting the latest developments in the field. The editors conclude the book by advocating for the establishment of professional grade Marine Biopharmacy courses at university level to contribute to this emerging field. This reference serves as a guide for researchers and instructors in disciplines such as Pharmaceutical Sciences, Marine Biology, Marine Microbiology, Marine Biochemistry, and Marine Biotechnology. Moreover, it is positioned as a standard reference for libraries in colleges and universities, offering critical insights for drug companies engaged in the development of new drugs from marine biopharmaceuticals.

Handbook of Laparoscopy Instruments covers the essential components of laparoscopic instruments and technology. It presents accessible information covering key topics on the subject: Ø Basic and specialized laparoscopic instruments Ø Image production Ø Pneumoperitoneum maintenance Ø Ergonomics Ø Sterilization procedures Ø Optical devices Ø Operation theatre layout and setup Ø Operative hand instruments Ø Robotic Surgery This book is an indispensable resource recommended for students and surgical residents who need an understanding of instruments and procedures in laparoscopic surgery. It is also intended to help medical professionals who want to start laparoscopy units in their clinics.