Neurodegenerative disorders such as Amyotrophic lateral sclerosis
(ALS), Alzheimer’s disease (AD), Parkinson’s disease
(PD), Prion-related disorders (PrD) and Huntington’s disease
(HD) share a common neuropathology, primarily featuring the presence
of abnormal protein inclusions containing specific misfolded proteins.
These groups of diseases are now classified as Protein Misfolding
Disorders. This Ebook gives a comprehensive overview of the possible
mechanisms involved in Protein Misfolding Disorders and possible
therapeutic strategies to treat these diseases. The Ebook provides
the most recent evidence addressing the role of cellular stress
responses to neurological diseases, along with therapeutic strategies
to alleviate ER stress in a disease context.