The book presents recent advances in the field of angiogenesis and
antiangiogenesis. Starting with the hypothesis of Judah Folkman
that tumor growth is angiogenesis dependent, this area of research
now has a solid scientific foundation. Tumor growth, metastasis,
progression, dormancy and apoptosis depend on angiogenesis: several
clinical studies have shown a positive correlation between the number
of vessels in the tumor, metastasis formation and disease prognosis.
A number of approaches have been developed to inhibit tumor angiogenesis,
and numerous compounds discovered that inhibit angiogenesis, but
only a few of them proved effective in vivo and only a
couple of agents were able to induce tumor regression. These and
other related developments described in the book should prove to
be of interest to a large number of readers wishing to keep abreast
with the latest developments in the field.