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Recent
Patents on Drug Delivery & Formulation
ISSN: 1872-2113
Recent Patents on Drug Delivery
& Formulation
Volume 3, Number 3, November 2009
Contents
Recent Patents Review in Microencapsulation of Pharmaceuticals
Using the Emulsion Solvent Removal Methods Pp. 178-192
Wasfy M. Obeidat
[Abstract] [Full
Text Article]
[PMID: 19925442 PubMed - indexed for MEDLINE]
Mucoadhesive Vaginal Drug Delivery Systems Pp.
193-205
Füsun Acartürk
[Abstract] [Full
Text Article] [PMID:
19925443 PubMed - indexed for MEDLINE]
New Generation of Liposomes Called Archaeosomes
Based on Natural or Synthetic Archaeal Lipids as Innovative
Formulations for Drug Delivery Pp. 206-220
Thierry Benvegnu, Loïc Lemiègre and Sandrine
Cammas-Marion
[Abstract] [Full
Text Article]
[PMID:
19534669 PubMed - indexed for MEDLINE]
Herbal Remedies for the Treatment of Periodontal
Disease - A Patent Review Pp. 221-228
Pramod Kumar, Shahid H. Ansari and Javed Ali
[Abstract] [Full
Text Article] [PMID:
19925444 PubMed - indexed for MEDLINE]
Current Ocular Drug Delivery Challenges
for N-acetylcarnosine: Novel Patented Routes and
Modes of Delivery, Design for Enhancement of Therapeutic Activity
and Drug Delivery Relationships Pp. 229-265
Mark A. Babizhayev
[Abstract] [Full
Text Article]
[PMID:
19534670 PubMed - indexed for MEDLINE]
Patent Selections Pp. 266-268
[Full
Text Article]
Abstracts
[Back to top] [PMID:
19925442 PubMed - indexed for MEDLINE]
Recent Patents Review in Microencapsulation of Pharmaceuticals
Using the Emulsion Solvent Removal Methods
Wasfy M. Obeidat
[Full
Text Article]
Several methods and techniques are potentially useful
for the preparation of polymeric microparticles in the broad
field of microencapsulation. The preparation method determines
the type and the size of microparticle and influence the ability
of the interaction among the components used in microparticle
formulations. This review is devoted to describe and allocate
the recently awarded and pending patents regarding the technical
and formulation innovations in microparticles involved in
drug delivery that are based mainly on the emulsion solvent
removal methods. The term microparticle designates systems
larger than one micrometer in diameter and is used usually
to describe both microcapsules and microspheres. Microparticles-containing
drugs are employed for various purposes including -but not
restricted to- controlled drug delivery, masking the taste
and odor of drugs, protection of the drugs from degradation,
and protection of the body from the toxic effects of the drugs.
Polymeric carriers being essentially multidisciplinary are
commonly utilized in microparticle fabrication and they can
be of an erodible or a non-erodible type.
[Back to top]
[PMID:
19925443 PubMed - indexed for MEDLINE]
Mucoadhesive Vaginal Drug Delivery Systems
Füsun Acartürk
[Full
Text Article]
Vaginal delivery is an important route of drug administration
for both local and systemic diseases. The vaginal route has
some advantages due to its large surface area, rich blood
supply, avoidance of the first-pass effect, relatively high
permeability to many drugs and self-insertion. The traditional
commercial preparations, such as creams, foams, gels, irrigations
and tablets, are known to reside in the vaginal cavity for
a relatively short period of time owing to the self-cleaning
action of the vaginal tract, and often require multiple daily
doses to ensure the desired therapeutic effect. The vaginal
route appears to be highly appropriate for bioadhesive drug
delivery systems in order to retain drugs for treating largely
local conditions, or for use in contraception. In particular,
protection against sexually-transmitted diseases is critical.
To prolong the residence time in the vaginal cavity, bioadhesive
therapeutic systems have been developed in the form of semi-solid
and solid dosage forms. The most commonly used mucoadhesive
polymers that are capable of forming hydrogels are synthetic
polyacrylates, polycarbophil, chitosan, cellulose derivatives
(hydroxyethycellulose, hydroxy-propylcellulose and hydroxypropylmethylcellulose),
hyaluronic acid derivatives, pectin, tragacanth, carrageenan
and sodium alginate. The present article is a comprehensive
review of the patents related to mucoadhesive vaginal drug
delivery systems.
[Back to top] [PMID:
19534669 PubMed - indexed for MEDLINE]
New Generation of Liposomes Called Archaeosomes Based on Natural
or Synthetic Archaeal Lipids as Innovative Formulations for
Drug Delivery
Thierry Benvegnu, Loïc Lemiègre and
Sandrine Cammas-Marion
[Full
Text Article]
Archaeosomes made from natural archaeal membrane lipids
and/or synthetic lipid analogues have been extensively studied
for potential applications in drug and vaccine delivery over
the past decade only. Archaeal-type lipids consist of archaeol
(diether) and/or caldarchaeol (tetraether) core structures
wherein regularly branched and usually fully saturated phytanyl
chains (20-40 carbons in lengths), are attached via ether
bonds to the sn-2,3 carbons of the glycerol backbone. Archaeosomes
constitute a novel generation of liposomes that exhibit high
stabilities to low or high temperatures, acidic or alkaline
pH, oxidative conditions, high pressure, action of phospholipases,
bile salts and serum proteins. These properties associated
with a good safety profile are beneficial for nanotechnological
applications in drug and gene delivery. Additionally, archaeosome
formulations could be used as efficient carriers of antigens
and/or adjuvants promoting antigen-specific, humoral and cell-mediated
immune responses, in addition to antigen-specific mucosal
immune responses in the vaccinated hosts. The immune responses
are well sustained over time, and are subject to strong memory
responses. Nanodelivery-based vaccinations using archaeosomes
could then represent a promising approach for treating and
preventing infections, allergies, and neoplastic or cancer
diseases. In this review, the few recent US, World and European
patents developing archaeosomes for these biotechnological
applications in Health are discussed.
[Back to top]
[PMID:
19925444 PubMed - indexed for MEDLINE]
Herbal Remedies for the Treatment of Periodontal Disease
- A Patent Review
Pramod Kumar, Shahid H. Ansari and Javed
Ali
[Full
Text Article]
Periodontal diseases, if left unchecked, can lead to
major health problems. There are a number of traditional herbal
remedies for the treatment and management of diseases related
to teeth, gum and oral hygiene. Use of clove oil is an age
old remedy still practiced for periodontal problems. Our aim
is to present an overall view of the current strategies adopted
for the formulation and application of traditional herbal
remedies. The article provides a review of the patents obtained
on herbal remedies for the treatment of periodontal diseases.
In addition, it also provides an overall view of potent herbal
remedies widely used for periodontal diseases.
[Back to top]
[PMID: 19534670 PubMed - indexed for MEDLINE]
Current Ocular Drug Delivery Challenges for N-acetylcarnosine:
Novel Patented Routes and Modes of Delivery, Design for Enhancement
of Therapeutic Activity and Drug Delivery Relationships
Mark A. Babizhayev
[Full
Text Article]
This review article explores the functional activity
and development aspects of N-acetylcarnosine for
the visual system as revealed by the use of a variety of biophysical,
physiological and therapeutic ophthalmic methods. It is designed
for pharmacists and more advanced ophthalmology, optometry
and pharmacology researchers who wish to gain a basic understanding
of the biological effects of N-acetylcarnosine for
vision and to share in the excitement of the latest developments
in this field. Topics under the consideration include: ophthalmic
drug delivery of N-acetylcarnosine eye drops and
challenging endeavors facing the pharmaceutical scientist;
clinical and functional types of activity of the developed
and patented N-acetylcarnosine lubricant eye drops
designed as 1% N-acetylcarnosine prodrug of L-carnosine
containing a mucoadhesive cellulose-based compound combined
with corneal absorption promoters in a drug delivery system;
management of age-related serious or disabling eye diseases
in humans with N-acetylcarnosine eye drop therapeutic
platform (age-related cataracts, ocular inflammation, age-related
macular degeneration , macular dystrophies, ocular manifestations
of diabetes , hypertonic retinopathy, primary open angle glaucoma
, vitreous lesions) ; development and molecular mechanisms
of ocular therapeutic activities of carnosine derivatives
in the visual system. Through this article we can perceive
some helpful recent patents according to the title of the
issue. The biologically significant applications of carnosine
mimetics including those in ophthalmology were patented by
Dr. Babizhayev and the alliance Groups (WO2004028536A1; WO9419325;
WO9512581; WO2004064866A1).
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