Editor-in-Chief:

Dr. William A. Banks, MD
VAPSHCS/GRECC S-182
Building 1, Room 810A
1600 S. Columbian Way
Seattle, WA 98108
USA

Section Editors:

Howard Gendelman (University of Nebraska Med. Ctr., Omaha, NE, USA)
HIV Agents

Emilio Jirillo (Bari University, Bari, Italy)
Immune Agents
Alexander V. Kabanov (University of Nebraska Medical Center, Omaha, NE, USA)
Nanotechnology
Abba Kastin (Pennington Biomed. Res. Ctr., Baton Rouge, LA, USA)
Endocrine and Metabolic Agents
Gregory Lip (City Hospital, Birmingham, UK)
Anti-hypertensive Agents
Dimitri Mikhailidis (Royal Free Hospital, London, UK)
Cardiovascular/Hematologic Agents
Weihong Pan (Pennington Biomed. Res. Ctr., Baton Rouge, LA, USA)
Neurogenesis and Neural Repair
Rami Reddy (RR Labs Inc., San Diego, CA, USA)
Computer Assisted Drug Design


Editorial Advisory Board:

Mohammad Abdollahi (Tehran University of Medical Sciences, Tehran, Iran)
Scott A. Biller (Novartis Institutes for BioMedical Research, Cambridge, MA, USA)
Steven J. Brickner (Pfizer, Groton, CT, USA)
D. A. Butterfield (University of Kentucky, Lexington, KY, USA)
Giovanni Capranico (Istituto Nazionale Tumori, Milan, Italy)
Craig E. Caufield (Wyeth-Ayerst Research, Princeton, NJ, USA)
Daniel T.W. Chu (Chiron Corporation, Emeryville, CA, USA)
Errol B. De Souza (Neurocrine Biosciences, San Diego, CA, USA)
Elisabeth G.E. De Vries (Univ. of Groningen, Groningen, Netherlands)
Stevan W. Djuric (Abbott Laboratories, Abbott Park, IL, USA)
Annette M. Doherty
(Pfizer Global R & D, Sandwich, Kent, UK)
Roland E. Dolle (Pharmacopeia, Inc., Princeton, NJ, USA)
Catherine L. Farrell (Amgen, Inc.,Thousand Oaks, CA, USA)
Roger M. Freidinger (Merck Res. Laboratories, West Point, PA, USA)
Donald R. Gehlert (Lilly Research Laboratories, IN, USA)
Nigel H. Greig (National Institutes of Health, Baltimore, MD, USA)
James M. Hamby (Parke-Davis, Pharm. Res. Ann Arbor, MI, USA)
Tingjun Hou (Soochow University, Suzhou, Jiangsu, China)
Graham Johnson (Bristol-Myers Squibb, CT, USA)
Marlys Koschinsky (Queen's University, Kingston, Canada)
Kit S. Lam (UC Davis Cancer Center, Sacramento, CA, USA)
Wolfgang Langhans (Swiss Federal Inst. Tech., Schwerzenbach, Switzerland)
Hans Marquardt (Universität Hamburg, Hamburg, Germany)
John E. Morley (St. Louis Univ. Health Sciences Center, St. Louis, MO, USA)
John H. Musser (Glycomed, Alameda, CA, USA)
Martin Petkovich (Queen's University, Kingston, Canada)
Waldemar Priebe (University of Texas, Houston, TX, USA)
Des R. Richardson (University of Sydney, Sydney, NSW, Australia)
Andrew V. Schally Nobel laureate (VAMC, New Orleans, LA, USA)
George J. Schroepfer Jr. (Rice University, Houston, TX, USA)
Linus L. Shen (Abbott Laboratories, Abbott Park, IL, USA)
Seiji Shioda (Showa Univ. Sch. of Medicine, Shinagawa-ku, Tokyo, Japan)
Jeffrey D. Shmitt (Mol. Design & IT Group, North Carolina, USA)
William S. Sly (Saint Louis University School of Medicine, St. Louis, MO, USA)
Claudio Soto (University of Texas Medical Branch, Galveston, TX, USA)
Claudiu T. Supuran (Universita degli Studi di Firenze, Florence, Italy)
Tetsuya Terasaki (Graduate School of Pharmaceutical, Tohoku University, Sendai, Japan)
Nese Tuncel (Osmangazi University, Eskisehir, Turkey)
Franco Zunino (Istituto Nazionale Tumori, Milan, Italy)


Executive Guest Editors:

Old and new Pharmacotherapies in the Management of Patients with Alcohol Dependence
Giovanni Addolorato/Lorenzo Leggio (Italy)

New Strategies in the Search of Antipsychotic Drugs
Albert Adell (Spain)

Structural Insights of the MHC Molecule in the Design of Vaccines
Vasso Apostolopoulos (Australia)

Targeted Therapeutics - From Chemical Structures to Diagnostic and Therapeutic Agents
Christine Armbruster (Austria)

The Blood Brain Barrier in Health & Disease
William A. Banks (USA)

Phosphodiesterase 5 Inhibitors: Pharmacology and Therapeutic Perspectives
Giuseppe Barbaro (Italy)

The next Generation of Recombinant Human Immunotoxins
Stefan Barth (Germany)

Bipolar Depressions, Diagnosis and Treatment
Franco Benazzi (Italy)

Anti-Cancer Drugs
Elke S. Bergmann-Leitner (USA)

The HIV-1 Envelope Protein as Vaccine Candidate and Therapeutic Target
Ben Berkhout/Rogier Sanders (The Netherlands)

Anti-Angiogenesis Agents
Maurizio Botta (Italy)

Anti-Cancer Agents
Giovanni Capranico (Italy)

Oxidative Stress, Inflammation and type 2 Diabetes
Xilin Chen (USA)

Current Perspectives in the use of PUFA for Treatment of Human Diseases
Antonio Cherubini (Italy)

Molecularly Targeted Therapies in Breast Cancer Bone Metastasis
Philippe Clezardin (France)

Targeting Nitric Oxide for Tumor Therapy
Antonio Contestabile (Italy)

Pharmacological Modulation of Ischemia-Reperusion (I/R) Injury with Emphasis on Liver I/R Injury
Brian R. Davidson/Dimitri P Mikhailidis/George K Glantzounis (UK)

Death Receptor Ligands
E.G. Elisabeth de Vries (The Netherlands)

The Metabolic Treatment of Coronary Artery Disease and Heart Failure
Pericle Di Napoli (Italy)

Physical and Chemical Agents Inducing Cell Death and Differentiation
Roberta Di Pietro (Italy)

Parasite Polyamines as Pharmaceutical Targets
Marcos André Vannier dos Santos (Brazil)

Pharmaceutical Design of Novel Anticancer Agents: A Lesson from Nature
Ping Dou (USA)

The Multifactorial Nature of AD and related Therapeutic Strategies
Maria do carmo Carreiras (Portugal)

ECM in Health and Disease
Johannes A. Eble (Germany)

Pleiotropic Effects of Drugs used for the Prevention of Cardiovascular Diseases
M. Elisaf/E. Liberopoulos (Greece)

News in Therapy of Cardiomyopathy
Giovanni Fazio (Italy)

Biased Agonism at 7TMRs
Chris S. Flordellis (Greece)

Perspectives in Psychopharmacological Neuroimaging
Paolo Fusar-Poli (Italy)

Adipose Stem Cells as Pharmacological Targets and Discovery Tools
Jeffrey M. Gimble / Mark E. Nuttall (USA)

Tracers and Techniques for non-invasive in vivo Imaging of Beta-cells
Martin Gotthardt (The Netherlands)

Neuropeptide-based Drug Design
Illana Gozes (Israel)

Pharmacogenetics
Henk-Jan Guchelaar (The Netherlands)

Resistance in Gram-negative Pathogens: A Threat to Global Health
Nancy D. Hanson (USA)

Novel Approach for Potential Therapeutic Drugs of Schizophrenia
Kenji Hashimoto (Japan)

Membrane Channels as Therapeutic Targets/Therapeutic Potential of Peptide Motifs
Jean-Claude Hervé (France)

Bisphosphonates and Bone Diseases
Dominique Heymann (France)

Perspectives of Pharmacokinetics and Metabolism in Drug Design
Yunsheng Hsieh (USA)

Therapeutic Manipulation of the Immune System: Old and new Approaches
Emilio Jirillo (Italy)

Cell Adhesion Molecules: Function, Drug-Design and Biomaterials
Seetharama D.S. Jois (USA)

The Role of Radiopharmaceuticals in Drug Development
Kairemo Kalevi (Finland)

Pathophysiological basis and Prospects for Novel Therapies in Inflammatory Bowel Disease
Osamu Kanauchi (Japan)

Bipolar Disorder: Clinical Staging as a means to Guide Pharmacological Interventions
Flávio Kapczinski (Brazil)

Radiopharmaceuticals in Drug Discovery and Development
Michael Kassiou (Australia)

New Therapeutic Strategies for Treatment Neurodegenerative Diseases
Aleksey Kazantsev (USA)

The hypoxia-inducible factor (HIF) Pathway as a target for Prevention and Treatment of Clinical Manifestations
Thomas Kietzmann (Germany)

Current status of Drug Eluting Stents
Nicholas Kipshidze (USA)

Anti-Hypertensive Agents in Relation to Modifying Coronary Risk Factors
Aurelio Leone (Italy)

Antihypertensive Drugs
Gregory Y.H. Lip (UK)

New Antidepressant Drugs Beyond Monoaminergic Design
Francisco Lopez-Munoz (Spain)

The Endocannabinoid System in Neuroinflammatory Diseases
Mauro Maccarrone (Italy)

Angiogenesis gene therapy: New tools and Targets to Stimulate a Mature Neovasculature
Paolo Madeddu (UK)

Drugs Targeting atherosclerosis: Current and Emerging Approaches
Vangelis Manolopoulos (Greece)

Angiogenesis Agents
Cezary Marcinkiewicz (USA)

Therapeutic Angiogenesis and Regeneration in Cardiovascular Diseases
Takahashi Masafumi (Japan)

Therapeutic Intervention on virus Assembly
Mauricio G. Mateu (Spain)

Erythropoietin
Peter van der Meer (USA)

Effect on Serum Uric Acid Levels of Drugs Prescribed for Indications other than Treating Hyperuricaemia; 2) Lipid Lowering Treatment - An Update
Dimitri P. Mikhailidis (UK)

New generation cancer vaccines: From Tumor Immunology to Clinical Applications
Simone Mocellin (Italy)

Applications of ACE Inhibitors and A2 Receptor Blockers
Agostino Molteni (USA)

In silico approaches in G protein-coupled Receptors (GPCRs) Drug Discovery: Quo Vadis?
Stefano Moro (Italy)

ADAM family members as Therapeutic Targets
Marcia Moss (USA)

Exploiting Multivalency in Drug Design
Diego Munoz-Torrero (USA)

Spinal Cord Injury and Repair
Weihong Pan (USA)

Current Perspectives and Future Challenges in the Treatment of Arterial Stiffness and Central Hemodynamics
Theodoros Papaioannou (Greece)

HIV Drug Design (Anti-HIV Agents)
Keykavous Parang (USA)

Nicotinamide Adenine Dinucleotide Biology and Disease
W. Todd Penberthy (USA)

Molecular Mechanisms of Cancer Cell Death
Ricardo Perez-Tomas (USA)

HIV Entry: Achievements and Challenges
Stefan Pohlmann (Germany)

Central Neuropeptidergic Systems as Targets for Novel Psychiatric Drug Development
Robert Ring (USA)

Computer-assisted Drug design and discover from nature
Judith Rollinger (Austria)

HIV Drug Design and Therapy
Ted M. Ross (USA)

Frontiers in Child Psychiatric Pharmacological Treatment
A. Rothenberger (Germany)

Enzyme Inhibition
Michel Salzet (France)

Inhibitions of Tumor-associated Inflammation to Fight Cancer
Raymond Schiffelers (The Netherlands)

Molecular Biology of Sexual Dysfunction
Allen D. Seftel (USA)

Ion Channels as Therapeutic Targets for Neuropathic Pain
Char-Chang Shieh (USA)

Protein Misfolding Disorders
Claudio Soto (Switzerland)

New Mechanisms of Bacterial Resistance
Iris Spiliopoulou (Greece)

Latest Achievements in Zinc Enzymes: Structure, Inhibition & Drug Design
Georgios A. Spyroulias (Greece)

Autoimmune Diseases
D. Stahl/W. Sibrowski (Germany)

Carbonic Anhydrases as Drug Targets
Claudiu T. Supuran (Italy)

Ion Channels as a Target for Drug Design
Kwok-Keung Tai (USA)

The Adverse Effects of Chronic Inflammation on Cardiovascular Health
Paul-Peter Tak/Radjesh Bisoendial (The Netherlands)

The Search of Targets for Novel Antipsychotic Drugs
Akihiro Takano (Sweden)

Gastrointestinal (GI) Research
Koji Takeuchi (Japan)

Current Perspectives on Muscle Regeneration and Diseases
Gianluca Tettamanti/ Annalisa Grimaldi (Italy)

Recent Advances in Developmental Toxicology
Gian Mario Tiboni (Italy)

Adipocytokines and Fatty Liver Disease: Key Mediators Linking Fat and Inflammation
Herbert Tilg (Austria)

The Mechanisms of Bilirubin Cytotoxicity and its Translational Meanings
Claudio Tiribelli (Italy)

Treatment of Neuroblastoma: From MYCN-based Therapy to new Therapies
Gian Paolo Tonini (Italy)

Regulatory Peptides
Nese Tuncel (Turkey)

The Human Microbiome - a Therapeutic Target for Prevention and Treatment of Chronic Disease
Kieran Tuohy (UK)

Pharmaceutical and Cellular Strategies in Prophylaxis and Treatment of Graft-versus-Host Disease
George Tuszynski (USA)

Citokines and Inflammation Markers in Ischemic Stroke
Antonino Tuttolomondo (Italy)

Antisense Oligonucleotide
Bruce D. Uhal (USA)

Drug-induced Arrhythmias
Jamie Vandenberg (Australia)

Cytokine Genetics & Pharmacogenomics
Koen Vandenbroeck (The Netherlands)

Pharmacological Brain Imaging in the Healthy and Sick Brain
Freddy van der Veen (The Netherlands)

High Density Lipoproteins: anno 2008
Sophie van Linthout (UK)

Possible new Pharmacological Strategies for the Treatment of Supraventricular Arrhythmias
Andras Varro (Hungary)

Action and Evolution of Immunomodulatory Drugs
Mariateresa Ventura (Italy)

Glucocorticoids from Chemistry to Clinics
Forunato Vesce (Italy)

Oxidative Stress and Cellular Homeostasis
Victor Manuel Victor (Spain)

Targets of Metabolic Toxicity of HIV Antiretroviral Drugs: The Multiple Roads to Lipodystrophy and Metabolic Syndrome
Francesc Villarroya (Spain)

Protein-Protein Interactions. Application to the Development of New Antiviral Agents for the Treatment of HIV Infection
Michael Walker (USA)

Current Formulation Techniques of Drug Delivery Devices
Chi-Hwa Wang (Singapore)




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