Editor-in-Chief:

Dr. William A. Banks, MD
VAPSHCS/GRECC S-182
Building 1, Room 810A
1600 S. Columbian Way
Seattle, WA 98108
USA

Section Editors:

Howard Gendelman (University of Nebraska Med. Ctr., Omaha, NE, USA)
HIV Agents

Emilio Jirillo (Bari University, Bari, Italy)
Immune Agents
Alexander V. Kabanov (University of Nebraska Medical Center, Omaha, NE, USA)
Nanotechnology
Abba Kastin (Pennington Biomed. Res. Ctr., Baton Rouge, LA, USA)
Endocrine and Metabolic Agents
Gregory Lip (City Hospital, Birmingham, UK)
Anti-hypertensive Agents
Dimitri Mikhailidis (Royal Free Hospital, London, UK)
Cardiovascular/Hematologic Agents
Weihong Pan (Pennington Biomed. Res. Ctr., Baton Rouge, LA, USA)
Neurogenesis and Neural Repair
Rami Reddy (RR Labs Inc., San Diego, CA, USA)
Computer Assisted Drug Design

Editorial Advisory Board:

Scott A. Biller (Novartis Institutes for BioMedical Research, Cambridge, MA, USA)
Steven J. Brickner (Pfizer, Groton, CT, USA)
D. A. Butterfield (University of Kentucky, Lexington, KY, USA)
Giovanni Capranico (Istituto Nazionale Tumori, Milan, Italy)
Craig E. Caufield (Wyeth-Ayerst Research, Princeton, NJ, USA)
Daniel T.W. Chu (Chiron Corporation, Emeryville, CA, USA)
Errol B. De Souza (Neurocrine Biosciences, San Diego, CA, USA)
Elisabeth G.E. De Vries (Univ. of Groningen, Groningen, Netherlands)
Stevan W. Djuric (Abbott Laboratories, Abbott Park, IL, USA)
Annette M. Doherty (Pfizer Global R & D, Sandwich, Kent, UK)
Roland E. Dolle (Pharmacopeia, Inc., Princeton, NJ, USA)
Catherine L. Farrell (Amgen, Inc.,Thousand Oaks, CA, USA)
Roger M. Freidinger (Merck Res. Laboratories, West Point, PA, USA)
Nigel H. Greig (National Institutes of Health, Baltimore, MD, USA)
James M. Hamby (Parke-Davis, Pharm. Res. Ann Arbor, MI, USA)
Tingjun Hou (Soochow University, Suzhou, Jiangsu, China)
Graham Johnson (Bristol-Myers Squibb, CT, USA)
Keith W. Kelley (University of Illinois, IL, USA)
Marlys Koschinsky (Queen's University, Kingston, Canada)
Kit S. Lam (UC Davis Cancer Center, Sacramento, CA, USA)
Hans Marquardt (Universität Hamburg, Hamburg, Germany)
John E. Morley (St. Louis University Health Sciences Center, St. Louis, MO, USA)
John H. Musser (Glycomed, Alameda, CA, USA)
Martin Petkovich (Queen's University, Kingston, Canada)
Waldemar Priebe (University of Texas, Houston, TX, USA)
Des R. Richardson (University of Sydney, Sydney, NSW, Australia)
Andrew V. Schally Nobel laureate (VAMC, New Orleans, LA, USA)
George J. Schroepfer Jr. (Rice University, Houston, TX, USA)
Linus L. Shen (Abbott Laboratories, Abbott Park, IL, USA)
Seiji Shioda (Showa Univ. Sch. of Medicine, Shinagawa-ku, Tokyo, Japan)
Jeffrey D. Shmitt (Mol. Design & IT Group, North Carolina, USA)
William S. Sly (Saint Louis University School of Medicine, St. Louis, MO, USA)
Claudio Soto (University of Texas Medical Branch, Galveston, TX, USA)
Claudiu T. Supuran (Universita degli Studi di Firenze, Florence, Italy)
Tetsuya Terasaki (Graduate School of Pharmaceutical, Tohoku University, Sendai, Japan)
Nese Tuncel (Osmangazi University, Eskisehir, Turkey)
Xiaojun Yao (Lanzhou University, Lanzhou, China)
Franco Zunino (Istituto Nazionale Tumori, Milan, Italy)

Executive Guest Editors:

Systems and Network Biology in Pharmaceutical Drug Discovery
Asfar Azmi USA)

The snap-tag technology - a versatile biotechnological tool for different applications
Stefan Barth (Germany)

The G Protein-Coupled Estrogen Receptor: Molecular Pharmacology and Therapeutic Targets
Matthias Barton (Switzerland)

Anti-malarial Drug Discovery and Design in the Era of Resistance
Angus Bell (Ireland)

Leptin as a Therapeutic Target in Cardiovascular Diseases
Jerzy Beltowski (Poland)

Protonation states & conformational dynamics in ligand-target recognition & binding
Pier Giuseppe de Benedetti (Italy)

Neurobiological and Neurocognitive Basis of The Effects of Cannabinoids In Animals and Man: Therapeutic Potential of Cannabinoids In Psychiatry
Sagnik Bhattacharyya (UK)

Novel targets and biomarkers for anti-atherosclerotic therapy
Yuri Bobryshev (Australia)

Antioxidants in lifestyle and therapeutics of the elderly
Elena Chiarpotto & Giuseppe Poli (Italy)

miRNA in the pathogenesis and therapy for gastrointestinal and hepatic cancers
Chi Cho (China)

Radiolabbeled imaging probes for personalized imaging
Van Christophe (Belgium)

From medicinal plants to medicines in plants: A paradigm shift in using plants as factories for the production of valuable pharmaceuticals
Paul Christou (Spain)

Targeting histone acetylation for neuroprotection
Antonio Contestabile (Italy)

Molecular modeling and QSAR studies for drug design
José Correa-Basurto (Mexico)

Treating major age-related diseases in octogenarians: climbing the mountain while avoiding potential pitfalls of guidelines
Andrea Corsonello (Italy)

Crosstalk Between the Nervous and the Immune Systems in Health and in Sickness
Monica Del Rey (Spain)

Epigenetics and metabolic drug target for anticancer therapy
Alberto Del Rio (Italy)

Advances in the treatment of neurodegenerative diseases and epilepsy
Antonio Espuny (USA)

Achieving Current Goals in Prevention and Treatment of Vascular Disease: an update
Matilda Florentin (Greece)

Autoimmunity and Autoinflammation: Cardiovascular Drug Targets and Design
Armen Gasparyan (UK)

New insights in the insulin resistance, cardiovascular diseases and oxidative stress: pathophysiological and clinical consequences
Víctor González (Spain)

Current and future options for lipid-lowering therapy beyond statins
Ioanna Gouni-Berthold (Germany)

Mitochondrial Biogenesis: Pharmacological Approaches
Maria Teresa Valero Griñán (Greece)

Pharmacology and Biochemistry of Stereotyped Motor Behaviors
Pierre Guertin (Canada)

Design of optimized anti-TB drug regimens with keys from evolution and biological variability
Twanda Gumbo (USA)

Resistance in Gram-negative Pathogens: A Threat to Global Health
Nancy Hanson (USA)

Hepatitis Delta: Epidemiology, Pathogenesis and Therapy
Phillip Harrison (UK)

Plant Polyphenols and Health Benefits
Mamoru Isemura (Japan)

Updates in the Management of Acute Coronary Syndromes
Hani Jneid (USA)

Roles of anesthetics and opioids in organ or tissue protection
Hiroyuki Kinoshita (Japan)

Novel strategies for cardiac repair post-myocardial infarction
Theofilos Kolettis (Greece)

Bone Morphogenetic Proteins (BMPs) for Bone Regeneration and their alternatives
Cato Laurencin and Kevin Lo (USA)

The multidomain mobility lab in older persons: from bench to bedside
Fulvio Lauretani (Italy)

Cell penetrating peptides as delivery vectors for biomolecules
Bernard Lebleu (France)

Modifying Cardiovascular Risk Factors: New Markers of Cardiovascular Damage
Aurelio Leone (Italy)

Proteolysis and its control in health and disease
Adam Lesner (Poland)

Therapeutic strategies to target endothelial nitric oxide synthase (eNOS)
Huige Li (Denmark)

Drug Development Based on the Structure and Multiple Pharmacological Targets of Curcumin
Guang Liang (China)

Pharmacological and molecular targets in cellular redox status maintenance
Giovanni Li Volti (Italy)

Therapeutic Applications of Advanced Drug Delivery Systems
Carla Lopes and Ana Silva (Portugal)

Protein-protein interaction: from interface to interaction network
Buyong Ma (USA)

Plant-derived foods for the attenuation of allergic airway inflammation
Thea Magrone and Emilio Jirillo (Italy)

Therapeutics targeting the ubiquitin-proteasome system: current status and prospective
Xinliang Mao (China)

Flavoproteins and Flavoenzymes with Biomedical and Therapeutic Impact
Milagros Medina (Spain)

New Developments in the Prevention and Treatment of Vascular Disease – 3 Diabetes, obesity and vascular disease – an update
Dimitri Mikhailidis (UK)

The Lung and winding road: twists and turns on the way to personalized NSCLC therapy
Michele Milella (Italy)

Angiotensin II Receptors Research
Shin-ichrio Miura (Japan)

Cellular Senescence: Advances and Therapeutic Targets in Aging and Major Age-Related Diseases
Eugenio Mocchegiani (Italy)

In silico approaches in G protein-coupled receptors (GPCRs) drug discovery: quo vadis?
Stefano Moro (Italy)

Targeting Cell death and proliferation receptors in cancer
Jordi Muntané (Spain)

Rational Drug Design
Rami Mutyala (USA)

Molecular chaperones as drug targets
Hitoshi Nakamoto and Hiroyuki Osada (Japan)

Perspectives of antiarrhythmic therapy: new trails, challenges and pitfalls
Péter P. Nánási (Hungary)

Naturally occurring molecules and anticancer combination therapies in the era of personalized medicine and economic crisis
Silvio Naviglio (Italy)

Cardio-metabolic complications: current perspective and future developments
Joseph Ndisang (Canada)

Cystic Fibrosis: CFTR modulators and their mechanism of action
Erika Nieddu (Italy)

Targeting synaptic dysfunction and neural connectivity in neurological and psychiatric disorders
Robert Nistico (Italy)

Current perioperative therapy for patients with cardiovascular disease: addressing the new and optimizing the old
Jose Orriach (Spain)

Future trends in the development of new antidepressant drugs
Angel Pazos (Spain)

Therapeutic targets and pharmacological strategies in steatotic and non-steatotic liver transplantation
Carmen Peralta (Spain)

The Ubiquitin Proteasome System as a source of drug targets for cancer therapy
Paola Perego (Italy)

Invasive Aspergillosis: new insights into disease, diagnostic and treatment
Susanne Perkhofer (Austria)

Development of new molecular agents targeting key signalling pathways activated by growth factors in human cancer
Godefridus Peters (Netherlands)

Update on Treatment Strategies in Patients with Non-alcoholic Fatty Liver Disease
Salvatore Petta (Italy)

Pharmacological Prevention and Therapy of No Reflow in the Catheterization Laboratory: New Insights from Basic and Clinical Science
Italo Porto and Giampaolo Niccoli (Italy)

Pathophysiology And Therapeutics of Cardiovascular Health in Metabolic Syndrome
Jun Ren (USA)

Novel therapeutic targets in the Metabolic Syndrome
Manfredi Rizzo (Italy)

Cocaine and amphetamine-type stimulants: the search for pharmacological therapies
Marta Rodriguez-Arias (Spain)

Targeting Transporters for CNS Drug Delivery
Patrick Ronaldson (USA)

Disease control and Active and Healthy Ageing: new paradigms of therapeutic strategy
Patrizia Russo (Italy)

Parasite Polyamines as Pharmaceutical Targets
Marcos Santos (Brazil)

Current Perspectives and Challenges in Design, Chemistry and Pharmacology of Opioids
Helmut Schmidhammer and Mariana Spetea (Austria)

From gut inflammation to gastrointestinal disorders Current update on pathophysiology, molecular mechanism and pharmacological treatment modalities
Predrag Sikiric (Croatia)

New developments on NUCB2/nesfatin-1
Andreas Stengel and Yvette Tache (Germany)

The discovery of novel inhibitors for the treatment of HIV infection
JianJun Tan and Cunxin Wang (China)

Exploring molecular and clinical management of patients in the follow up of the hpv related uterine lesions
Andrea Tinelli (Italy)

Mitochondria and subcellular organelles as treatment target against pathological conditions
Antonio Toninello (Italy)

Targeting the Metabolism of Cancer Cells
Miguel Torres (Spain)

Stable angina pectoris: novel therapeutic insights
Dimitris Tousoulis (Greece)

Soluble beta amyloid in a continuum from physiology to pathology: searching the determinants of its effects and designing new pharmacological treatments
Luigia Trabace (Italy)

Anderson Fabry disease : A multiorgan metabolic disease susceptible of treatment
Bruno Tuttolomondo (Italy)

Neonatal and Pediatric Clinical Pharmacology
John van den Anker (USA)

Nanotechnology in Pharmaceutical Design
Zhi Xu (Australia)

Novel therapeutic targets for cardiovascular disease
Sho-ichi Yamagishi (Japan)

Therapy at the Nano Dimension
Bing Yan (USA)

Targeting Neuregulin1 and ErbB2 for Therapy of Breast Cancer and Heart Failure
Xinhua Yan (USA)

Rational Drug Design with the Aid of Molecular Modeling and Bioinformatics
Yongliang Yang (China)

Mechanisms and Therapeutic Strategies for Ischemic Brain Injury: Current Advances and Future Perspectives
Weihai Ying (China)

Novel Formulation Strategies for Poorly Water-soluble Drugs and Herbal Medicines
Zheng Ying (Macau)

Recent Progress and Future Potential for Metal-Based Drugs
Jinchao Zhang (China)

MicroRNA-regulated replication specificity of oncolytic virotherapy for cancer
Junnian Zheng (China)

Molecular understanding of pain and future treatment of chronic pain
Min Zhuo (Canada)