Current Medicinal Chemistry –

Immunology, Endocrine & Metabolic Agents

 

 

Contents

 

 

Preface   The Metabolic Syndrome: From Pathophysiology to Novel Treatment Strategies Cynthia Arbeeny, Robert Sacchiero and Michael Booker

Ab oligomerization: A Therapeutic Target for Alzheimer's Disease D. R. Howlett

Direct Vascular Targets For Atherosclerosis Prevention Brian R. Krause, Bruce J. Auerbach and Thomas M. A. Bocan

Central Self-Tolerance by Thymic Presentation of Self-Antigens and Autoimmunity Vincent Geenen, Henri Martens, Fabienne Brilot, Isabelle Hansenne and Ouafae Kecha-Kamoun

Carbonic Anhydrase Inhibitors Claudiu T. Supuran and Andrea Scozzafava

Nutritional Antioxidants: Mechanisms of Action, Analyses of Activities and Medical Applications Jacob Vaya and Michael Aviram

 

This is to acknowledge that the slide shown on the front cover of this journal was kindly supplied by Prof. Claudiu T. Supuran, Università degli Studi, Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, I-50121 Florence, Italy. The figure shows hCA II active site, with the Zn(II) ion (pink sphere), its three histidine ligands (His 94, His 96 and His 119, in green), the proton shuttle residue His 64 as well as the histidine cluster extending from the rim of the active site to the surface of the protein, comprising residues 3, 4, 10, 15 and 17 – in orange).