Upcoming Articles of Current Drug Metabolism:

Contents


Characterization of single nucleotide polymorphisms of cytochrome P450 in an Australian deceased sample
Jennifer L. Pilgrim, Yarimar Ruiz, Alejandro Gesteira, Raquel Cruz, Dimitri Gerostamoulos, Angel Carracedo and Olaf H. Drummer

Absorption, Disposition, and Pharmacokinetics of Saponins from Chinese Medicinal Herbs: What Do We Know and What Do We Need to Know More?
Ke Yu, Feng Chen and Chuan Li

Metabolite profiling and characterization for medicinal herbal remedies
Min Yang, Chunru Cheng, Junling Yang and De-an Guo

Herb-Drug Interactions and Mechanistic and Clinical Considerations
Shu-Ming He, Kevin B. Sneed, Xiao-Wu Chen, Chuanhai Cao and Shu-Feng Zhou

Intestinal Absorption and Presystemic Elimination of Various Chemical Constituents Present in GBE50 Extract, a Standardized Extract of Ginkgo Biloba Leaves
Li Li, Yuansheng Zhao, Feifei Du, Junling Yang, Fang Xu, Wei Niu, Yaohui Ren and Chuan Li

Metabolite profiling and Pharmacokinetics of Herbal Compounds Following Oral Administration of a Cardiovascular Multi-herb Medicine (Qishen Yiqi Pills) in rat
Yufeng Zhang, Peiying Shi, Hong Yao, Qing Shao and Xiaohui Fan

Aptamers as remarkable diagnostic and therapeutic agents in cancer treatment
Henri-Pierre Lassalle, Sophie Marchal, François Guillemin, Aurélie Reinhard and Lina Bezdetnaya

In vivo biodistribution, pharmacokinetics, and toxicology of carbon nanotubes
Kai Yang and Zhuang Liu

Nano-based drug delivery system enhances the oral absorption of lipophilic drugs with extensive presystemic metabolism
Zhiwen Zhang, Fang Gao, Shijun Jiang, Li Ma and Yaping Li

Dendrimers in cancer therapeutics and diagnosis
Rui Guo and Xiangyang Shi

Fluorescent Carbon Dots and Nanodiamonds for Biological Imaging: Preparation, Application, Pharmacokinetics and Toxicity
Jia-Hui Liu, Sheng-Tao Yang, Xinxin Chen and Haifang Wang

Co-delivery strategies based on multifunctional nanocarriers for cancer therapy
Hao Chen, Ying Zhao, Hai Wang, Guangjun Nie and Kaihui Nan

Toxicological Profile of Therapeutic Nanodelivery Systems
Luis M. Bimbo, Leena Peltonen, Jouni Hirvonen and Hélder A. Santos

Impacts of nanoparticles on cardiovascular diseases: modulating metabolism and function of endothelial cells
Jie Meng, Xian-da Yang, Lee Jia, Xing-Jie Liang and Chen Wang

Nanoparticles improve biological functions of phthalocyanine photosensitizers used for photodynamic therapy
Xiao Jia and Lee Jia

Fullerenes for Cancer Diagnosis and Therapy: Preparation, Biological and Clinical Perspectives
Zhiyun Chen, Ruoqing Mao and Ying Liu

Sex Differences In The Clearance Of Cyp3a4 Substrates: Exploring Possible Reasons For The Substrate Dependency And Lack Of Consensus
Manoranjenni Chetty, Donald Mattison and Amin Rostami-Hodjegan

Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics during Pregnancy: Achievements and Shortcomings
G. Lu, K. Abduljalil, M. Jamei, T.N. Johnson, H. Soltani and A. Rostami-Hodjegan

Pharmacotherapy in neonatal and pediatric extracorporeal membrane oxygenation (ECMO)
E.D. Wildschut, M.J Ahsman, R.J. Houmes, P. Pokorna, S.N. de Wildt, R.A.A. Mathot and D. Tibboel

Ontogeny of Hepatic Glucuronidation; Methods and Results
Elke Henriëtte Josephina Krekels, Meindert Danhof and Dick Tibboel

Growing up with midazolam in the neonatal and pediatric intensive care
Eleonora L. Swart, Pauline R. Slort and Frans B. Plötz

Pharmacokinetic Considerations of Perinatal Antiretroviral Therapy
Natella Y. Rakhmanina, Sahera Dirajlal-Fargo, Edmund V. Capparelli and Mark Mirochnik

Pharmacogenetics of opioids for the treatment of acute maternal pain during pregnancy and lactation
Parvaz Madadi, Denise Avard and Gideon Koren

The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics
Yan Li, Jun Lu and James W. Paxton

Roles of UDP-glucuronosyltransferases in Phytochemical Metabolism of Herbal Medicines and the Associated Herb-drug Interactions
Li Li, Haihong Hu, Siyun Xu, Quan Zhou and Su Zeng

Interactions between Phytochemicals from Traditional Chinese Medicines and Human Cytochrome P450 Enzymes
Jing-Jing Wu, Chun-Zhi Ai, Yong Liu, Yan-Yan Zhang, Miao Jiang and Ai-Ping Lv Ling Yang

Drug metabolism and pharmacokinetics of nanodrugs from Chinese medicines and natural products
Chang-Xiao Liu, Duan-Yun Si, Xue-Feng Xiao, Xin He and Ya-Zhuo Li

Pharmacokinetics-Pharmacology Disconnection of Herbal Medicines and Its Potential Solutions with Cellular Pharmacokinetic-Pharmacodynamic Strategy
Jingwei Zhang, Fang Zhou, Meng Lu, Wei Ji, Fang Niu, Weibin Zha, Xiaolan Wu, Haiping Hao and Guangji Wang

De-Risking Bio-therapeutics for Possible Drug Interactions Using Cryopreserved Human Hepatocytes
Shannon Dallas, Carlo Sensenhauser, Ameesha Batheja, Monica Singer, Maria Markowska, Cindy Zakszewski, Rao N.V.S. Mamidi, Michael McMillian, Chao Han, Honghui Zhou and Jose Silva

Drug Interaction Potential of Trastuzumab Emtansine Combined With Pertuzumab in Patients With HER2-Positive Metastatic Breast Cancer
Dan Lu, Howard A Burris III, Bei Wang, E Claire Dees, Javier Cortes, Amita Joshi, Manish Gupta, Joo-Hee Yi, Yu-Waye Chu, Ted Shih, Liang Fang and Sandhya Girish

Effects of Interleukin 1β (IL-1β) and IL-1β /Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture
Leslie J. Dickmann, Sonal K. Patel, Larry C. Wienkers and J. Greg Slatter

Animal Models for Evaluation of Drug-Drug Interaction Potential of Biotherapeutics
Eugenia Kraynov, Martin E. Dowty, Odette A. Fahmi and Owen Fields

Catabolic Fate and Pharmacokinetic Characterization of Trastuzumab Emtansine T-DM1: An Emphasis on Preclinical and Clinical Catabolism
Ben-Quan Shen, Daniela Bumbaca, Ola Saad, Qin Yue, Cinthia V. Pastuskovas, S. Cyrus Khojasteh, Jay Tibbitts, Surinder Kaur, Bei Wang, Yu-Waye Chu, Patricia M. LoRusso and Sandhya Girish

Effects of Culture Duration on Gene Expression of P450 Isoforms, Uptake and Efflux Transporters in Primary Hepatocytes Cultured in the Absence and Presence of Interleukin- 6: Implications for Experimental Design for the Evaluation of Downregulatory Effects of Biotherapeutics
Qian Yang, Utkarsh Doshi, Nicole Li and Albert P. Li

Disposition and Interaction of Biotherapeutics in Pediatric Populations
Souzan Yanni

Strategies For Improving The Quantitative Bioanalytical Performance Of Lc–Ms In Pharmacokinetic Studies
Li Li, Dandan Tian, Junling Yang, Feng Chen, Ke Yu and Yan Sun


Isotopic labeling of metabolites in drug discovery applications
Jacobo Iglesias, Lekha Sleno and Dietrich A. Volmer

Liquid Chromatography-Mass Spectrometric Multiple Reaction Monitoring-based Strategies for Expanding Targeted Profiling towards Quantitative Metabolomics
Bin Guo, Bo Chen, Aiming Liu, Weitao Zhu and Shouzhuo Yao

LC/MS Based Tools and Strategies on Qualitative and Quantitative Analysis of Herbal Components in Complex Matrixes
Liang Wu, Haiping Hao and Guangji Wang

Lc-Ms Based Screening And Targeted Profiling Methods For Complex Plant: Coffee A Case Study
Jeane Santos da Rosa, Otniel Freitas-Silva, Sidney Pacheco, Ronoel Luiz de Oliveira Godoy and Claudia Maria Moraes Rezende


Importance of Metabolic Activation Study to the Safe Use of Chinese Herbal Medicines
Bin Ma, Na Li and Ge Lin

Metabolic Conversion from Co-existing Ingredient Leading to Significant Systemic
Exposure of Z-butylidenephthalide, a Minor Ingredient in Chuanxiong Rhizoma in
Rat
Ru Yan, Nga Ling Ko, Bin Ma, Yun Kau Tam and Ge Lin

Measurement of CYP1A2 Activity: A Focus on Caffeine as a Probe
Vidya Perera, Annette S. Gross and Andrew J. McLachlan

Uptake and metabolism of the short-chain fatty acid butyrate, a critical review of the literature
Stuart M. Astbury and Bernard M. Corfe

Active Metabolites Resulting from Decarboxylation, Reduction and Ester Hydrolysis of Parent Drugs
I. Hartyánszky, H, Kalász , E. Adeghate , Zs. Gulyás, M.Y. Hasan, K. Tekes, A. Adem and P. Sótonyi

Summary of Information on the Effects of Ionizing and Non-ionizing Radiation on Cytochrome P450 and Other Drug Metabolizing Enzymes and Transporters
Slobodan Rendic and F. Peter Guengerich

Physiologically Based Pharmacokinetic Models: Integration of In Silico Approaches with Micro Cell Culture Analogues
T. Maguire, A. Chen and M.L.Yarmush

Intracellular Disposition of Methotrexate in Acute Lymphoblastic Leukemia in Children
Tiphaine Adam de Beaumais and Evelyne Jacqz-Aigrain

Comparison of Cytochrome P450 2C Subfamily Members in Terms of Drug Oxidation Rates and Substrate Inhibition
Toshiro Niwa and Hiroshi Yamazaki

Implications of Nanoscale Based Drug Delivery Systems in Delivery and Targeting Tubulin Binding Agent, Noscapine in Cancer Cells
Ramesh Chandra, Jitender Madan, Prashant Singh, Ankush Chandra, Pradeep Kumar, Vritika Tomar and Sujata K. Dass