In this issue of BenSci, the Editor’s Pick Section will start through a selection of articles published in the February 2012 issues of Bentham Science major journals. This is a way to make readers alert on the most updated achievements in the field of biomedicine and drug targeting. In the next sections, picks from other prestigious international journals will follow covering various aspects of medical sciences and therapeutic interventions with special reference to Cardiology,Neurology, Gerontology, Gastroenterology, Immunology and Infectious Diseases.
Sarwat Aziz Abbasi, Editor BenSci
Pick of the Month (by Emilio Jirillo, University of Bari, Bari, Italy)
Resveratrol, a neuroprotective supplement for Alzheimer’s disease.
Li F, Gong Q, Dong H, Shi J
Current Pharmaceutical Design 18: 27-33, 2012.
"In this review article, Authors point out the activities of resveratrol, a polyphenolic compound widely distributed in the plant kingdom. In particular, the neuroprotective effects of resveratrol are described in various experimental settings. Current data indicate that resveratrol is able to cleave the amyloid precursor protein and enhance clearance of amyloid beta-peptides, thus reducing neuronal damage. Authors conclude that resveratrol may represent a promising nutraceutical therapy in the course of human Alzheimer, even if additional data on bioavailability and biotransformation of this compound are still needed."
Anti cancer activities of thea epigallocatechin-3-gallate (EGCG) in breast cancer patients under radiotherapy.
Zhang G, Wang Y, Zhang X, Wan J, Li K, Liu F et al.
Current Molecular Medicine 12: 163-76, 2012
"EGCG, a polyphenol present in tea, was administered to breast cancer patients under radiotherapy at the dosage of 400 mg capsules 3 times/day in comparison to patients receiving
radiotherapy only (controls). In patients with combined therapy (EGCG plus radiotherapy) serum levels of vascular endothelial growth factor, hepatocyte growth factor and metalloproteinase (MMP)-9 and -2 were lower than in controls. Moreover, sera from patients with combined treatment were able to suppress in vitro cell proliferation, invasion and activation of MMP-9 and MMP-2 of a human breast cancer line. Furthermore, these tumor cells exposed to EGCG underwent a high apoptosis following gamma-radiation with reduction of NFKB induction and AKT phosphorylation.
Authors conclude that EGCG may represent a promising therapeutic adjuvant in the treatment of metastatic breast cancer."
The regulation of FoxP3-expressing regulatory T cells
Haque R, Lei F, Xiong X, Song T.
Endocrine Metabolic Immune Disorders-Drug Targets 11 : 334-46, 2011.
"FoxP3 expression in T regulatory (TREG) cells represents a critical factor in the TREG cell suppressive function. This review elucidates the mechanisms of action of these cells, even including cell contact-dependent and cytokine-dependent modalities. Authors conclude that acquisition of basic knowledge on the function of TREG cells would be very important in the design of therapeutic strategies aimed at the modulation of T regulation in the course of chronic inflammatory diseases."