News & Views
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Selection from 'Protein & Peptide Letters'

Dear Reader,

The News & Views section of the first issue of BenSci 2010 presents a selection of ten recently published papers in ‘Protein & Peptide Letters’ ( I hope this will be interesting for you.

Best regards,

Prof. Ben M. Dunn, PhD


Behrens, M.; Buck, F.; Meyerhof, W. Substrate Specificity of Rat DESC4, A Type II Transmembrane Serine Protease, Protein and Peptide Letters, 2009, 16(1), 1-6.

'This manuscript deals with an important new enzyme type, the transmembrane serine proteases. These are involved in cellular signaling, host immune defense, prohormone processing, and cancer development.’

Rizzi, L.; Vaiana, N.; Sagui, F.; Genesio, E.; Pilli, E.; Porcari, V.; Romeo, S. Design, Synthesis and Docking Studies of Hydroxyethylamine and Hydroxyethylsulfide BACE-1 Inhibitors, Protein and Peptide Letters, 2009, 16(1), 86-90.

‘Understanding the function of BACE-1 will be important in treatment of neurodegenerative conditions such as Alzheimer’s disease. The Romeo group has created synthetic inhibitors targeted for this critical enzyme and presented studies of how they fit into the active site.’

T.L. Emmons, T.L.; A.M. Mildner, A.M.; J.M. Lull, J.M.; J.W. Leone, J.W., H.D. Fischer, R.L. Heinrikson; A.G. Tomasselli Large Scale Refolding and Purification of the Catalytic Domain of Human BACE-2 Produced in E. coli, Protein and Peptide Letters, 2009, 16(2), 121-131.



‘BACE-2 is another enzyme that may be important in neurodegeneration. Heinrikson and Tomasselli and their colleagues present another paper full of experimental detail on the preparation and analysis of a new drug target. This work could serve as an example for training new students in this important work.’

Sakudo, A.; Ikuta, K. Fundamentals of Prion Diseases and Their Involvement in the Loss of Function of Cellular Prion Protein, Protein and Peptide Letters, 16(3), 217-229.

‘The authors address diseases arising from the effects of prions and their conversion between the non-pathogenic and the pathogenic forms. This paper presents information on the history of prion studies as well as new experimental results on studies of various forms of the prion protein.'

Vassalo, N. Properties and Pathogenicity of Prion-Derived Peptides, Protein and Peptide Letters, 16(3), 230-238.

‘The properties and functions of a specific fragment of the prion protein are described in this paper, which emphasizes the physiochemical characteristics and interactions with lipid membranes. This study emphasizes the importance of using defined peptides prepared by synthetic chemistry rather than heterogenous preparations to achieve results with high confidence.

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