M.; Buck, F.; Meyerhof, W. Substrate
Specificity of Rat DESC4, A Type II Transmembrane
Serine Protease, Protein and Peptide Letters,
2009, 16(1), 1-6.
manuscript deals with an important new enzyme
type, the transmembrane serine proteases.
These are involved in cellular signaling,
host immune defense, prohormone processing,
and cancer development.
L.; Vaiana, N.; Sagui, F.; Genesio, E.;
Pilli, E.; Porcari, V.; Romeo, S. Design,
Synthesis and Docking Studies of Hydroxyethylamine
and Hydroxyethylsulfide BACE-1 Inhibitors,
Protein and Peptide Letters, 2009, 16(1),
the function of BACE-1 will be important
in treatment of neurodegenerative conditions
such as Alzheimer’s disease. The Romeo group
has created synthetic inhibitors targeted
for this critical enzyme and presented studies
of how they fit into the active site.
Emmons, T.L.; A.M. Mildner, A.M.; J.M. Lull,
J.M.; J.W. Leone, J.W., H.D. Fischer, R.L.
Heinrikson; A.G. Tomasselli Large Scale
Refolding and Purification of the Catalytic
Domain of Human BACE-2 Produced in E. coli,
Protein and Peptide Letters, 2009, 16(2),