News & Views

Selection from 'Current Topics in Medicinal Chemistry'

Dear Reader,

The News & Views section of the first issue of BenSci 2009 presents a selection of ten recently published papers in Current Topics in Medicinal Chemistry ( I hope this will be interesting for you.

Best regards,

Allen Reitz
, PhD


Lagrutta, A. A.; Trepakova, E.; Salata, J. J. The hERG Channel and Risk of Drug-Acquired Cardiac Arrhythmia: An Overview. Curr. Top. Med. Chem. 2008, 8, 1102-1112.

Being able to understand the monitor hERG channel activity is a very important part of any modern drug discovery program. This comprehensive review discussed the correlation between hERG channel binding and activity and drug-induced cardiac arrhythmias in humans.’

Aronov, A. M. Ligand Structural Aspects of hERG Channel Blockade. Curr. Top. Med. Chem. 2008, 8, 1113-1127.

‘This article discusses the relationship of structure to binding and inhibition at the hERG channel.Ê This is very important to understand in order to try to direct the medicinal chemistry of any particular chemical series away from this dangerous side effect site of action.’

Renger J. J. Overview of Experimental and Conventional Pharmacological Approaches in the Treatment of Sleep and Wake Disorders. Curr. Top. Med. Chem. 2008, 8, 937-953.

‘Insomnia is a pervasive condition that lowers quality of life. This review discusses the types of


tests and analysis that are used to evaluation potential drug candidates to treat this disorder.’

Feldman, P. L.; Lambert, M. H.; Henke, B. R. PPAR Modulators and PPAR Pan Agonists for Metabolic Diseases: The Next Generation of Drugs Targeting Peroxisome Proliferator-Activated Receptors?Ê Curr. Top. Med. Chem. 2008, 8, 728-749.

‘The therapeutic and commercial success of PPAR agonists such as rosiglitazone have prompted research into finding new and improved agents acting at one or more of the PPAR sites of action.

This comprehensive review covers the state of the art in this field at the present time.’
Baltz, R. H. Biosynthesis and Genetic Engineering of Lipopeptide Antibiotics Related to Daptomycin. Curr. Top. Med. Chem. 2008, 8, 618-638.

‘Daptomycin is used clinically to treat complicated topical infections caused by Gram-positive pathogens, and for certain infections caused by S. aureus. This review discusses the search for new related lipopeptide antibiotics using modern techniques of chemical and molecular biology

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