A. A.; Trepakova, E.; Salata, J. J. The hERG Channel and Risk of Drug-Acquired
Cardiac Arrhythmia: An Overview. Curr. Top. Med. Chem. 2008, 8, 1102-1112.
Being able to understand the monitor hERG channel activity is
a very important part of any modern drug discovery program. This comprehensive
review discussed the correlation between hERG channel binding and activity
and drug-induced cardiac arrhythmias in humans.
Aronov, A. M. Ligand Structural Aspects of hERG
Channel Blockade. Curr. Top. Med. Chem. 2008, 8, 1113-1127.
This article discusses the relationship of structure to binding
and inhibition at the hERG channel.Ê This is very important to
understand in order to try to direct the medicinal chemistry of any
particular chemical series away from this dangerous side effect site
Renger J. J. Overview of
Experimental and Conventional Pharmacological Approaches in the Treatment
of Sleep and Wake Disorders. Curr. Top. Med. Chem. 2008, 8, 937-953.
Insomnia is a pervasive condition that lowers quality of life.
This review discusses the types of