The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex^® - A Cannabis-derived Spray

Title:The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex^® - A Cannabis-derived Spray

Volume: 24 Issue: 15

Author(s): Sina Motamedy, Bahareh Soltani, Halimeh Kameshki, Asmae Alipour kermani, Reza Saboori Amleshi, Masoud Nazeri and Mohammad Shabani*

Affiliation:

• Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran

Keywords: Sativex, multiple sclerosis, neuroprotective, amyotrophic lateral sclerosis, antitumoral, huntington's disease.

Abstract: Sativex is a cannabis-based medicine that comes in the form of an oromucosal spray. It contains equal amounts of Δ9-tetrahydrocannabinol and cannabidiol, two compounds derived from cannabis plants. Sativex has been shown to have positive effects on symptoms of amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and sleep disorders. It also has analgesic, antiinflammatory, antitumoral, and neuroprotective properties, which make it a potential treatment option for other neurological disorders. The article reviews the results of recent preclinical and clinical studies that support the therapeutic potential of Sativex and the molecular mechanisms behind its neuroprotective benefits in various neurological disorders. The article also discusses the possible advantages and disadvantages of using Sativex as a neurotherapeutic agent, such as its safety, efficacy, availability, and legal status.

Cite this article as:

Motamedy Sina, Soltani Bahareh, Kameshki Halimeh, Alipour kermani Asmae, Saboori Amleshi Reza, Nazeri Masoud and Shabani Mohammad*, The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex^® - A Cannabis-derived Spray, Mini-Reviews in Medicinal Chemistry 2024; 24 (15) . https://dx.doi.org/10.2174/0113895575285934240123110158