Clinical Trials of Mesenchymal Stem Cells for the Treatment of COVID 19

Title:Clinical Trials of Mesenchymal Stem Cells for the Treatment of COVID 19

Volume: 19 Issue: 8

Author(s): Elham Zendedel, Lobat Tayebi, Mohammad Nikbakht, Elham Hasanzadeh*Shiva Asadpour*

Affiliation:

• Immunogenetics Research Center, Department of Tissue Engineering & Regenerative Medicine, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran

• Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
• Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Keywords: Covid-19, mesenchymal stem cell (MSCs), clinical trials, cell therapy, regenerative medicine, SARS-CoV-2.

Abstract: Mesenchymal Stem Cells (MSCs) are being investigated as a treatment for a novel viral disease owing to their immunomodulatory, anti-inflammatory, tissue repair and regeneration characteristics, however, the exact processes are unknown. MSC therapy was found to be effective in lowering immune system overactivation and increasing endogenous healing after SARS-CoV-2 infection by improving the pulmonary microenvironment. Many studies on mesenchymal stem cells have been undertaken concurrently, and we may help speed up the effectiveness of these studies by collecting and statistically analyzing data from them. Based on clinical trial information found on clinicaltrials. gov and on 16 November 2020, which includes 63 clinical trials in the field of patient treatment with COVID-19 using MSCs, according to the trend of increasing studies in this field, and with the help of meta-analysis studies, it is possible to hope that the promise of MSCs will one day be realized. The potential therapeutic applications of MSCs for COVID-19 are investigated in this study.

Cite this article as:

Zendedel Elham, Tayebi Lobat, Nikbakht Mohammad, Hasanzadeh Elham*, Asadpour Shiva*, Clinical Trials of Mesenchymal Stem Cells for the Treatment of COVID 19, Current Stem Cell Research & Therapy 2024; 19 (8) . https://dx.doi.org/10.2174/011574888X260032230925052240